| 7. Round | 25/08/1980 | RC Strasbourg | - | AS Monaco | 0:0 | ||||
| 8. Round | 28/08/1980 | AS Monaco | - | US Valenciennes-Anzin | 5:1 | ||||
| 9. Round | 08/09/1980 | AJ Auxerre | - | AS Monaco | 0:0 | ||||
| 10. Round | 11/09/1980 | FC Metz | - | AS Monaco | 1:1 | ||||
| 12. Round | 25/09/1980 | Stade Lavallois | - | AS Monaco | 3:3 | ||||
| 13. Round | 04/10/1980 | AS Monaco | - | FC Sochaux | 2:1 | ||||
| 16. Round | 30/10/1980 | Nîmes Olympique | - | AS Monaco | 1:3 | ||||
| 18. Round | 11/11/1980 | Girondins Bordeaux | - | AS Monaco | 1:0 | ||||
| 19. Round | 22/11/1980 | AS Monaco | - | OGC Nice | 1:0 | ||||
| 20. Round | 28/11/1980 | Lille OSC | - | AS Monaco | 2:1 | ||||
| 21. Round | 06/12/1980 | AS Monaco | - | Olympique Lyonnais | 2:1 | ||||
| 22. Round | 12/12/1980 | Angers SCO | - | AS Monaco | 1:1 | ||||
| 23. Round | 19/12/1980 | AS Monaco | - | SC Bastia | 3:0 | ||||
| 26. Round | 07/02/1981 | US Valenciennes-Anzin | - | AS Monaco | 0:1 | ||||
| 28. Round | 27/02/1981 | AS Monaco | - | FC Metz | 2:1 | ||||
| 32. Round | 14/04/1981 | AS Monaco | - | RC Lens | 1:0 | ||||
| 37. Round | 28/05/1981 | OGC Nice | - | AS Monaco | 2:1 |
France