| 1. Round | 07/08/2021 | FC Lorient B | - | AS Vitré | 1:0 | ||||
| 2. Round | 14/08/2021 | FC Versailles | - | FC Lorient B | 0:0 | ||||
| 3. Round | 21/08/2021 | FC Lorient B | - | US Saint-Malo | 2:0 | ||||
| 4. Round | 28/08/2021 | Stade Plabennec | - | FC Lorient B | 1:1 |  |
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| 7. Round | 18/09/2021 | FC Lorient B | - | SM Caen B | 0:1 | ||||
| 8. Round | 25/09/2021 | FC Lorient B | - | EA Guingamp B | 3:0 | ||||
| 10. Round | 23/10/2021 | FC Lorient B | - | C'Chartres Football | 3:2 | ||||
| 11. Round | 06/11/2021 | Châteaubriant Voltigeurs | - | FC Lorient B | 2:0 | ||||
| 12. Round | 20/11/2021 | FC Lorient B | - | Vannes OC | 1:0 | ||||
| 13. Round | 04/12/2021 | US Granvillaise | - | FC Lorient B | 0:0 | ||||
| 14. Round | 11/12/2021 | FC Lorient B | - | SO Romorantin | 4:0 | ||||
| 16. Round | 22/01/2022 | FC Lorient B | - | FC Versailles | 1:1 | ||||
| 17. Round | 05/02/2022 | US Saint-Malo | - | FC Lorient B | 2:0 | ||||
| 18. Round | 12/02/2022 | FC Lorient B | - | Stade Plabennec | 1:0 | ||||
| 27. Round | 29/04/2022 | FC Lorient B | - | US Granvillaise | 0:1 |
France