| 1. Round | 06/08/2021 | Angoulême CFC | - | AS Béziers | 0:0 | ||||
| 4. Round | 27/08/2021 | Bergerac Périgord FC | - | AS Béziers | 2:0 | ||||
| 5. Round | 04/09/2021 | AS Béziers | - | Stade Montois | 3:2 | ||||
| 6. Round | 11/09/2021 | Bourges Foot 18 | - | AS Béziers | 0:1 | ||||
| 7. Round | 18/09/2021 | AS Béziers | - | Le Puy Foot 43 | 2:1 | ||||
| 8. Round | 25/09/2021 | Angers SCO B | - | AS Béziers | 2:0 | ||||
| 9. Round | 08/10/2021 | AS Béziers | - | Vendée Les Herbiers | 1:1 | ||||
| 10. Round | 23/10/2021 | Montpellier HSC B | - | AS Béziers | 2:0 | ||||
| 11. Round | 06/11/2021 | AS Béziers | - | FC Chamalières | 1:2 |
France