| 1. Round | 29/08/2021 | AS Saint-Priest [Youth B] | - | AC Ajaccio [Youth B] | 0:1 | ||||
| 2. Round | 05/09/2021 | AC Ajaccio [Youth B] | - | OGC Nice [Youth B] | 2:0 | ||||
| 3. Round | 12/09/2021 | Clermont Foot 63 [Youth B] | - | AC Ajaccio [Youth B] | 3:0 | ||||
| 4. Round | 19/09/2021 | AC Ajaccio [Youth B] | - | SC Air Bel [Youth B] | 2:1 | ||||
| 5. Round | 26/09/2021 | AS Monaco [Youth B] | - | AC Ajaccio [Youth B] | 1:4 | ||||
| 7. Round | 10/10/2021 | Andrézieux-Bouthéon FC [Youth B] | - | AC Ajaccio [Youth B] | 0:3 | ||||
| 8. Round | 16/10/2021 | AC Ajaccio [Youth B] | - | Olympique Marseille [Youth B] | 1:1 | ||||
| 9. Round | 24/10/2021 | Olympique de Valence [Youth B] | - | AC Ajaccio [Youth B] | 2:1 | ||||
| 10. Round | 14/11/2021 | Castelnau Le Crès FC [Youth B] | - | AC Ajaccio [Youth B] | 0:2 | ||||
| 11. Round | 20/11/2021 | AC Ajaccio [Youth B] | - | Racing FC Toulon [Youth B] | 1:1 |
France