| 3. Round | 28/07/2021 | Independiente | - | Patronato de Paraná | 2:0 | ||||
| 4. Round | 01/08/2021 | Platense | - | Independiente | 1:1 |  |
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| 5. Round | 09/08/2021 | Independiente | - | Racing Club | 1:0 | |
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| 6. Round | 15/08/2021 | Rosario Central | - | Independiente | 1:2 | ||||
| 7. Round | 21/08/2021 | Independiente | - | Defensa y Justicia | 0:0 | ||||
| 8. Round | 24/08/2021 | Atlético Tucumán | - | Independiente | 2:0 | |
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| 9. Round | 29/08/2021 | Independiente | - | Colón de Santa Fe | 3:0 | ||||
| 10. Round | 06/09/2021 | River Plate | - | Independiente | 1:1 | ||||
| 11. Round | 13/09/2021 | Independiente | - | Lanús | 0:1 | ||||
| 12. Round | 19/09/2021 | Huracán | - | Independiente | 0:1 | ||||
| 13. Round | 26/09/2021 | Independiente | - | Godoy Cruz | 1:4 | |
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| 18. Round | 26/10/2021 | Independiente | - | Unión de Santa Fe | 1:0 | ||||
| 19. Round | 31/10/2021 | Newell's Old Boys | - | Independiente | 1:0 | ||||
| 20. Round | 06/11/2021 | Independiente | - | Arsenal de Sarandí | 3:0 | ||||
| 25. Round | 13/12/2021 | Talleres de Córdoba | - | Independiente | 1:2 |
Argentina