| 3. Round | 12/09/2021 | Chamois Niortais [Youth B] | - | Angers SCO [Youth B] | 2:1 | ||||
| 4. Round | 19/09/2021 | Angers SCO [Youth B] | - | EA Guingamp [Youth B] | 7:0 |  |
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| 5. Round | 26/09/2021 | La Roche VF [Youth B] | - | Angers SCO [Youth B] | 0:2 | ||||
| 6. Round | 03/10/2021 | Angers SCO [Youth B] | - | CPBB Rennes [Youth B] | 9:1 | |
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| 7. Round | 10/10/2021 | Angoulême CFC [Youth B] | - | Angers SCO [Youth B] | 0:8 | ||||
| 8. Round | 17/10/2021 | Angers SCO [Youth B] | - | Vannes OC [Youth B] | 7:0 | ||||
| 9. Round | 23/10/2021 | FC Nantes [Youth B] | - | Angers SCO [Youth B] | 2:1 | ||||
| 10. Round | 14/11/2021 | Angers SCO [Youth B] | - | USSA Vertou [Youth B] | 3:2 | ||||
| 11. Round | 21/11/2021 | Angers SCO [Youth B] | - | LB Châteauroux [Youth B] | 4:2 | ||||
| 12. Round | 28/11/2021 | SO Cholet [Youth B] | - | Angers SCO [Youth B] | 2:4 | ||||
| 13. Round | 05/12/2021 | Angers SCO [Youth B] | - | FC Lorient [Youth B] | 0:3 | ||||
| 18. Round | 06/03/2022 | CPBB Rennes [Youth B] | - | Angers SCO [Youth B] | 0:5 | ||||
| 25. Round | 01/05/2022 | FC Lorient [Youth B] | - | Angers SCO [Youth B] | 0:3 |
France