| 1. Round | 29/08/2021 | FC Annecy [Youth B] | - | SAS Épinal [Youth B] | 2:1 | ||||
| 2. Round | 05/09/2021 | SAS Épinal [Youth B] | - | Dijon FCO [Youth B] | 1:1 | ||||
| 3. Round | 12/09/2021 | FC Mulhouse [Youth B] | - | SAS Épinal [Youth B] | 2:0 | ||||
| 4. Round | 19/09/2021 | FC Lyon [Youth B] | - | SAS Épinal [Youth B] | 2:0 | ||||
| 9. Round | 24/10/2021 | SAS Épinal [Youth B] | - | Racing Besançon [Youth B] | 3:1 | ||||
| 10. Round | 14/11/2021 | AJ Auxerre [Youth B] | - | SAS Épinal [Youth B] | 3:0 | ||||
| 11. Round | 21/11/2021 | SAS Épinal [Youth B] | - | FC Metz [Youth B] | 0:5 | ||||
| 12. Round | 28/11/2021 | Olympique Lyonnais [Youth B] | - | SAS Épinal [Youth B] | 5:0 | ||||
| 14. Round | 16/01/2022 | Dijon FCO [Youth B] | - | SAS Épinal [Youth B] | 3:1 | ||||
| 17. Round | 13/02/2022 | AS Nancy Lorraine [Youth B] | - | SAS Épinal [Youth B] | 3:0 | ||||
| 15. Round | 20/02/2022 | SAS Épinal [Youth B] | - | FC Mulhouse [Youth B] | 0:1 | ||||
| 22. Round | 03/04/2022 | SAS Épinal [Youth B] | - | AJ Auxerre [Youth B] | 2:3 | ||||
| 24. Round | 17/04/2022 | SAS Épinal [Youth B] | - | Olympique Lyonnais [Youth B] | 1:5 | ||||
| 26. Round | 15/05/2022 | SAS Épinal [Youth B] | - | FC Annecy [Youth B] | 2:2 |
France