| 1. Round | 22/08/2021 | Olympique Marseille [Youth] | - | Nîmes Olympique [Youth] | 7:3 | ||||
| 4. Round | 12/09/2021 | Nîmes Olympique [Youth] | - | Toulouse FC [Youth] | 0:1 | ||||
| 5. Round | 19/09/2021 | FC Istres [Youth] | - | Nîmes Olympique [Youth] | 5:1 | ||||
| 6. Round | 26/09/2021 | Nîmes Olympique [Youth] | - | Pieve di Lota [Youth] | 4:1 | ||||
| 7. Round | 03/10/2021 | AS Monaco [Youth] | - | Nîmes Olympique [Youth] | 4:2 | ||||
| 9. Round | 17/10/2021 | AC Ajaccio [Youth] | - | Nîmes Olympique [Youth] | 3:0 | ||||
| 12. Round | 21/11/2021 | AS Béziers [Youth] | - | Nîmes Olympique [Youth] | 3:0 | ||||
| 19. Round | 06/03/2022 | Nîmes Olympique [Youth] | - | AS Monaco [Youth] | 0:2 | ||||
| 21. Round | 27/03/2022 | Nîmes Olympique [Youth] | - | AC Ajaccio [Youth] | 1:1 | ||||
| 22. Round | 03/04/2022 | Nîmes Olympique [Youth] | - | AS Saint-Étienne [Youth] | 1:2 | ||||
| 23. Round | 10/04/2022 | Montpellier HSC [Youth] | - | Nîmes Olympique [Youth] | 3:0 | ||||
| 26. Round | 14/05/2022 | Nîmes Olympique [Youth] | - | Olympique Marseille [Youth] | 2:3 |
France