| 2. Round | 19/02/2021 | Newell's Old Boys II | - | Boca Juniors II | 1:3 | ||||
| 6. Round | 19/03/2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 3:1 | ||||
| 9. Round | 09/04/2021 | Lanús II | - | Newell's Old Boys II | 4:6 | ||||
| 10. Round | 16/04/2021 | Newell's Old Boys II | - | Patronato de Paraná II | 1:0 | ||||
| 11. Round | 23/04/2021 | Gimnasia de La Plata II | - | Newell's Old Boys II | 0:0 |
Argentina
Italy