| 1. Round | 16/07/2021 | Newell's Old Boys II | - | Talleres de Córdoba II | 2:1 | ||||
| 2. Round | 23/07/2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 3. Round | 27/07/2021 | Newell's Old Boys II | - | Estudiantes II | 1:3 | ||||
| 6. Round | 16/08/2021 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 7. Round | 20/08/2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 13. Round | 24/09/2021 | Newell's Old Boys II | - | Huracán II | 2:0 | ||||
| 14. Round | 01/10/2021 | Godoy Cruz II | - | Newell's Old Boys II | 1:1 | ||||
| 19. Round | 29/10/2021 | Newell's Old Boys II | - | Independiente II | 1:0 |
Argentina
Italy