| 1. Round | 18/07/2021 | Huracán | - | Defensa y Justicia | 2:1 |  |
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| 2. Round | 25/07/2021 | Defensa y Justicia | - | Godoy Cruz | 1:2 | ||||
| 3. Round | 28/07/2021 | Vélez Sarsfield | - | Defensa y Justicia | 0:0 | ||||
| 4. Round | 01/08/2021 | Defensa y Justicia | - | Gimnasia de La Plata | 3:2 | ||||
| 8. Round | 25/08/2021 | Defensa y Justicia | - | Newell's Old Boys | 2:0 | ||||
| 10. Round | 03/09/2021 | Defensa y Justicia | - | Central Córdoba SdE | 1:1 | ||||
| 23. Round | 28/11/2021 | Defensa y Justicia | - | Colón de Santa Fe | 1:1 | ||||
| 24. Round | 06/12/2021 | River Plate | - | Defensa y Justicia | 2:3 | ||||
| 25. Round | 12/12/2021 | Defensa y Justicia | - | Lanús | 2:1 |
Argentina