| 5. Round | 08/08/2021 | Godoy Cruz | - | River Plate | 2:1 | ||||
| 7. Round | 23/08/2021 | Gimnasia de La Plata | - | River Plate | 1:1 | ||||
| 8. Round | 27/08/2021 | River Plate | - | Aldosivi | 2:0 | ||||
| 21. Round | 22/11/2021 | Platense | - | River Plate | 0:1 | ||||
| 22. Round | 26/11/2021 | River Plate | - | Racing Club | 4:0 | ||||
| 23. Round | 28/11/2021 | Rosario Central | - | River Plate | 2:2 |
Argentina