| 1. Round | 25/07/2015 | 1. FC Slovácko | - | FK Dukla Praha | 4:3 | ||||
| 2. Round | 01/08/2015 | FK Teplice | - | 1. FC Slovácko | 2:0 | ||||
| 3. Round | 09/08/2015 | Viktoria Plzeň | - | 1. FC Slovácko | 2:2 | ||||
| 4. Round | 16/08/2015 | 1. FC Slovácko | - | 1. FK Příbram | 2:1 |  |
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| 5. Round | 22/08/2015 | Vysočina Jihlava | - | 1. FC Slovácko | 1:2 | ||||
| 6. Round | 12/09/2015 | 1. FC Slovácko | - | Slovan Liberec | 1:2 | ||||
| 12. Round | 31/10/2015 | 1. FC Slovácko | - | FK Jablonec | 1:1 | ||||
| 13. Round | 07/11/2015 | FC Fastav Zlín | - | 1. FC Slovácko | 2:1 | |
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| 16. Round | 04/12/2015 | 1. FC Slovácko | - | FK Teplice | 4:2 | ||||
| 17. Round | 14/02/2016 | 1. FC Slovácko | - | Viktoria Plzeň | 1:2 | ||||
| 18. Round | 20/02/2016 | 1. FK Příbram | - | 1. FC Slovácko | 0:1 | ||||
| 19. Round | 27/02/2016 | 1. FC Slovácko | - | Vysočina Jihlava | 3:1 | |
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| 20. Round | 06/03/2016 | Slovan Liberec | - | 1. FC Slovácko | 0:0 | ||||
| 21. Round | 12/03/2016 | 1. FC Slovácko | - | Zbrojovka Brno | 2:1 |  |
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| 22. Round | 19/03/2016 | Bohemians Praha 1905 | - | 1. FC Slovácko | 2:0 | ||||
| 27. Round | 30/04/2016 | 1. FC Slovácko | - | FC Fastav Zlín | 1:1 | ||||
| 28. Round | 08/05/2016 | Slavia Praha | - | 1. FC Slovácko | 5:1 | |
Czech Republic