| 6. Round | 21/09/2021 | Athletic Club | - | Rayo Vallecano | 1:2 |  |
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| 11. Round | 26/10/2021 | Espanyol Barcelona | - | Athletic Club | 1:1 | ||||
| 12. Round | 31/10/2021 | Real Sociedad | - | Athletic Club | 1:1 | ||||
| 13. Round | 05/11/2021 | Athletic Club | - | Cádiz CF | 0:1 | ||||
| 9. Round | 01/12/2021 | Real Madrid | - | Athletic Club | 1:0 | ||||
| 18. Round | 19/12/2021 | Athletic Club | - | Real Betis | 3:2 | ||||
| 21. Round | 22/12/2021 | Athletic Club | - | Real Madrid | 1:2 | ||||
| 24. Round | 14/02/2022 | RCD Mallorca | - | Athletic Club | 3:2 | ||||
| 30. Round | 03/04/2022 | Athletic Club | - | Elche CF | 2:1 | |
Spain