| 2. Round | 05/09/2021 | Tours FC [Youth B] | - | Havre AC [Youth B] | 0:5 | ||||
| 3. Round | 12/09/2021 | Blois Foot 41 [Youth B] | - | Tours FC [Youth B] | 0:1 | ||||
| 6. Round | 03/10/2021 | Tours FC [Youth B] | - | SM Caen [Youth B] | 2:1 | ||||
| 8. Round | 17/10/2021 | Tours FC [Youth B] | - | FC Rouen 1899 [Youth B] | 1:2 | ||||
| 9. Round | 24/10/2021 | Montrouge FC [Youth B] | - | Tours FC [Youth B] | 1:1 | ||||
| 10. Round | 14/11/2021 | Tours FC [Youth B] | - | Paris FC [Youth B] | 0:4 | ||||
| 12. Round | 28/11/2021 | US Avranches [Youth B] | - | Tours FC [Youth B] | 2:1 | ||||
| 13. Round | 05/12/2021 | Tours FC [Youth B] | - | CS Brétigny [Youth B] | 3:4 | ||||
| 20. Round | 20/03/2022 | FC Rouen 1899 [Youth B] | - | Tours FC [Youth B] | 2:1 | ||||
| 22. Round | 03/04/2022 | Paris FC [Youth B] | - | Tours FC [Youth B] | 4:0 | ||||
| 25. Round | 01/05/2022 | CS Brétigny [Youth B] | - | Tours FC [Youth B] | 4:3 |  |
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| 26. Round | 15/05/2022 | Tours FC [Youth B] | - | FC Mantois [Youth B] | 2:4 | |
France