| 1. Round | 07/08/2021 | Trélissac FC | - | Moulins Yzeure Foot | 0:2 | ||||
| 2. Round | 14/08/2021 | AS Béziers | - | Trélissac FC | 2:0 | ||||
| 3. Round | 21/08/2021 | Trélissac FC | - | Stade Montois | 3:1 |  |
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| 4. Round | 28/08/2021 | Bourges Foot 18 | - | Trélissac FC | 2:0 | ||||
| 5. Round | 04/09/2021 | Trélissac FC | - | Le Puy Foot 43 | 0:1 | ||||
| 6. Round | 11/09/2021 | Angers SCO B | - | Trélissac FC | 0:1 | ||||
| 7. Round | 18/09/2021 | Trélissac FC | - | Vendée Les Herbiers | 0:0 | ||||
| 8. Round | 25/09/2021 | Montpellier HSC B | - | Trélissac FC | 1:2 | ||||
| 9. Round | 09/10/2021 | Trélissac FC | - | FC Chamalières | 3:1 | ||||
| 10. Round | 23/10/2021 | Andrézieux-Bouthéon FC | - | Trélissac FC | 0:1 | ||||
| 25. Round | 16/04/2022 | US Colomiers | - | Trélissac FC | 1:1 | ||||
| 26. Round | 23/04/2022 | Trélissac FC | - | FC Nantes B | 1:0 | |
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| 27. Round | 30/04/2022 | Canet Roussillon | - | Trélissac FC | 1:2 |
Burundi