| 3. Round | 25/09/2021 | SD Eibar [Women] | - | Athletic Club [Women] | 1:2 | ||||
| 4. Round | 29/09/2021 | Valencia CF [Women] | - | Athletic Club [Women] | 1:3 | ||||
| 7. Round | 17/10/2021 | Athletic Club [Women] | - | Villarreal CF [Women] | 2:1 | ||||
| 8. Round | 31/10/2021 | Real Betis [Women] | - | Athletic Club [Women] | 4:2 |  |
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| 9. Round | 06/11/2021 | Athletic Club [Women] | - | Levante UD [Women] | 2:3 | ||||
| 10. Round | 14/11/2021 | Rayo Vallecano [Women] | - | Athletic Club [Women] | 0:2 | ||||
| 11. Round | 20/11/2021 | Athletic Club [Women] | - | Sporting de Huelva [Women] | 2:2 | ||||
| 17. Round | 12/01/2022 | Athletic Club [Women] | - | Real Betis [Women] | 1:1 | ||||
| 18. Round | 16/01/2022 | Levante UD [Women] | - | Athletic Club [Women] | 2:3 | |
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| 21. Round | 06/02/2022 | Sporting de Huelva [Women] | - | Athletic Club [Women] | 2:0 | ||||
| 25. Round | 26/03/2022 | Villarreal CF [Women] | - | Athletic Club [Women] | 1:1 | ||||
| 26. Round | 02/04/2022 | Athletic Club [Women] | - | Valencia CF [Women] | 2:2 | ||||
| 27. Round | 17/04/2022 | Atlético Madrid [Women] | - | Athletic Club [Women] | 3:0 | ||||
| 30. Round | 15/05/2022 | Athletic Club [Women] | - | Sevilla FC [Women] | 1:4 |
Spain