| 4. Round | 29/09/2021 | Atlético Madrid [Women] | - | CD Alavés [Women] | 3:2 | ||||
| 5. Round | 02/10/2021 | FC Barcelona [Women] | - | CD Alavés [Women] | 9:1 | ||||
| 7. Round | 17/10/2021 | Madrid CFF [Women] | - | CD Alavés [Women] | 0:1 | ||||
| 12. Round | 05/12/2021 | CD Alavés [Women] | - | Valencia CF [Women] | 3:1 | ||||
| 14. Round | 19/12/2021 | CD Alavés [Women] | - | Levante UD [Women] | 1:1 | ||||
| 16. Round | 08/01/2022 | Villarreal CF [Women] | - | CD Alavés [Women] | 3:1 | ||||
| 19. Round | 30/01/2022 | CD Alavés [Women] | - | Atlético Madrid [Women] | 1:1 | ||||
| 20. Round | 02/02/2022 | Real Betis [Women] | - | CD Alavés [Women] | 4:1 | ||||
| 21. Round | 06/02/2022 | CD Alavés [Women] | - | Sevilla FC [Women] | 1:1 | ||||
| 23. Round | 06/03/2022 | CD Alavés [Women] | - | FC Barcelona [Women] | 0:6 | ||||
| 26. Round | 03/04/2022 | SD Eibar [Women] | - | CD Alavés [Women] | 2:0 | ||||
| 27. Round | 17/04/2022 | CD Alavés [Women] | - | Real Madrid [Women] | 0:1 | ||||
| 29. Round | 07/05/2022 | CD Alavés [Women] | - | Athletic Club [Women] | 1:3 |
Spain