| 8. Round | 13/11/2021 | Stade de Reims [Women] | - | Dijon FCO [Women] | 1:1 | ||||
| 9. Round | 21/11/2021 | Paris Saint-Germain [Women] | - | Stade de Reims [Women] | 7:0 | ||||
| 10. Round | 04/12/2021 | Stade de Reims [Women] | - | ASJ Soyaux [Women] | 3:1 | ||||
| 11. Round | 12/12/2021 | AS Saint-Étienne [Women] | - | Stade de Reims [Women] | 0:1 | ||||
| 12. Round | 15/01/2022 | Stade de Reims [Women] | - | FC Fleury 91 [Women] | 0:1 | ||||
| 13. Round | 22/01/2022 | Girondins Bordeaux [Women] | - | Stade de Reims [Women] | 3:1 |  |
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| 14. Round | 05/02/2022 | Stade de Reims [Women] | - | GPSO 92 Issy [Women] | 4:3 |  |
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| 16. Round | 12/03/2022 | EA Guingamp [Women] | - | Stade de Reims [Women] | 0:1 | ||||
| 17. Round | 19/03/2022 | Stade de Reims [Women] | - | Paris FC [Women] | 1:2 | ||||
| 18. Round | 02/04/2022 | Montpellier HSC [Women] | - | Stade de Reims [Women] | 1:2 | ||||
| 19. Round | 16/04/2022 | ASJ Soyaux [Women] | - | Stade de Reims [Women] | 1:2 | ||||
| 20. Round | 07/05/2022 | Stade de Reims [Women] | - | AS Saint-Étienne [Women] | 1:0 | ||||
| 21. Round | 28/05/2022 | Dijon FCO [Women] | - | Stade de Reims [Women] | 2:2 | |
France