| 2. Round | 01/08/2021 | Dinamo Kiev | - | NK Veres | 4:0 |  |
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| 3. Round | 08/08/2021 | Zorya Lugansk | - | Dinamo Kiev | 1:2 | ||||
| 1. Round | 11/08/2021 | Dinamo Kiev | - | FC Mynai | 2:0 | ||||
| 4. Round | 18/08/2021 | Inhulets Petrove | - | Dinamo Kiev | 1:1 | ||||
| 5. Round | 22/08/2021 | Dinamo Kiev | - | Desna Chernigov | 4:0 | |
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| 6. Round | 28/08/2021 | Dinamo Kiev | - | Kolos Kovalivka | 7:0 | |
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| 7. Round | 11/09/2021 | Metalist 1925 Kharkiv | - | Dinamo Kiev | 0:2 | |
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| 8. Round | 18/09/2021 | Dinamo Kiev | - | FK Oleksandriya | 1:0 | |
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| 9. Round | 25/09/2021 | Rukh Lviv | - | Dinamo Kiev | 0:2 | |
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| 10. Round | 03/10/2021 | Dinamo Kiev | - | Shakhtar Donetsk | 0:0 | ||||
| 11. Round | 16/10/2021 | FK Lviv | - | Dinamo Kiev | 1:4 | |
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| 12. Round | 24/10/2021 | Dinamo Kiev | - | SK Dnipro-1 | 2:0 | |
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| 13. Round | 30/10/2021 | FK Mariupol | - | Dinamo Kiev | 2:3 | ||||
| 14. Round | 06/11/2021 | Dinamo Kiev | - | Vorskla Poltava | 1:2 | ||||
| 15. Round | 19/11/2021 | Chernomorets Odessa | - | Dinamo Kiev | 1:6 |  |
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| 16. Round | 27/11/2021 | FC Mynai | - | Dinamo Kiev | 0:2 | |
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| 17. Round | 04/12/2021 | NK Veres | - | Dinamo Kiev | 0:3 | |
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| 18. Round | 12/12/2021 | Dinamo Kiev | - | Zorya Lugansk | 1:1 |
Israel
