| 1. Round | 07/08/2021 | RC Grasse | - | Lyon-La Duchère | 1:0 | ||||
| 2. Round | 14/08/2021 | AS Monaco B | - | RC Grasse | 0:1 | ||||
| 8. Round | 25/09/2021 | Aubagne FC | - | RC Grasse | 1:0 | ||||
| 9. Round | 09/10/2021 | RC Grasse | - | Jura Sud | 1:4 | ||||
| 10. Round | 23/10/2021 | Olympique Marseille B | - | RC Grasse | 1:2 |  |
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| 11. Round | 06/11/2021 | RC Grasse | - | Marignane Gignac FC | 2:0 | ||||
| 12. Round | 20/11/2021 | Olympique Lyonnais B | - | RC Grasse | 1:0 | |
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| 14. Round | 11/12/2021 | RC Grasse | - | Louhans-Cuiseaux | 0:0 | ||||
| 16. Round | 22/01/2022 | RC Grasse | - | AS Monaco B | 0:0 | ||||
| 15. Round | 29/01/2022 | Hyères FC | - | RC Grasse | 1:1 | |
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| 17. Round | 05/02/2022 | FC Martigues | - | RC Grasse | 2:0 | ||||
| 18. Round | 12/02/2022 | RC Grasse | - | GFA Rumilly Vallières | 1:1 | |
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| 23. Round | 26/03/2022 | Jura Sud | - | RC Grasse | 1:2 | ||||
| 24. Round | 09/04/2022 | RC Grasse | - | Olympique Marseille B | 3:1 | ||||
| 25. Round | 16/04/2022 | Marignane Gignac FC | - | RC Grasse | 1:2 | |
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| 26. Round | 23/04/2022 | RC Grasse | - | Olympique Lyonnais B | 2:1 | ||||
| 28. Round | 14/05/2022 | Louhans-Cuiseaux | - | RC Grasse | 3:1 | ||||
| 29. Round | 21/05/2022 | RC Grasse | - | Hyères FC | 4:2 | ||||
| 30. Round | 28/05/2022 | Lyon-La Duchère | - | RC Grasse | 0:3 |
France