| 1. Round | 11/01/2021 | Club León [Women] | - | Deportivo Toluca [Women] | 0:2 | ||||
| 2. Round | 19/01/2021 | Club Tijuana [Women] | - | Deportivo Toluca [Women] | 0:1 | ||||
| 3. Round | 25/01/2021 | Deportivo Toluca [Women] | - | Gallos Blancos [Women] | 1:0 | ||||
| 4. Round | 01/02/2021 | CF América [Women] | - | Deportivo Toluca [Women] | 2:2 | ||||
| 8. Round | 02/03/2021 | UANL Tigres [Women] | - | Deportivo Toluca [Women] | 2:0 | ||||
| 10. Round | 12/03/2021 | Deportivo Guadalajara [Women] | - | Deportivo Toluca [Women] | 1:1 | ||||
| 11. Round | 14/03/2021 | CF Monterrey [Women] | - | Deportivo Toluca [Women] | 1:0 | ||||
| 13. Round | 27/03/2021 | Atlas Guadalajara [Women] | - | Deportivo Toluca [Women] | 1:2 | ||||
| 14. Round | 05/04/2021 | Deportivo Toluca [Women] | - | Mazatlán FC [Women] | 1:0 | ||||
| 15. Round | 19/04/2021 | Deportivo Toluca [Women] | - | Santos Laguna [Women] | 1:0 | ||||
| 17. Round | 03/05/2021 | Deportivo Toluca [Women] | - | Pumas UNAM [Women] | 0:1 |
Mexico