| 2. Round | 31/07/2021 | Cercle Brugge | - | Oud-Heverlee Leuven | 1:1 |  |
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| 3. Round | 06/08/2021 | Club Brugge KV | - | Cercle Brugge | 1:1 | |
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| 4. Round | 15/08/2021 | Cercle Brugge | - | RSC Anderlecht | 1:2 |  |
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| 5. Round | 21/08/2021 | RFC Seraing | - | Cercle Brugge | 2:1 | ||||
| 6. Round | 28/08/2021 | Cercle Brugge | - | Sint-Truidense VV | 0:1 | ||||
| 7. Round | 11/09/2021 | SV Zulte Waregem | - | Cercle Brugge | 2:4 | ||||
| 8. Round | 17/09/2021 | Cercle Brugge | - | KAS Eupen | 1:2 | ||||
| 10. Round | 02/10/2021 | Cercle Brugge | - | Union Saint-Gilloise | 0:3 | |
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| 11. Round | 16/10/2021 | KV Oostende | - | Cercle Brugge | 2:1 | ||||
| 15. Round | 20/11/2021 | Cercle Brugge | - | Sporting Charleroi | 1:2 | ||||
| 16. Round | 27/11/2021 | Cercle Brugge | - | KV Mechelen | 3:1 |
Spain