| 2. Round | 05/09/2021 | Tours FC [Youth B] | - | Havre AC [Youth B] | 0:5 | ||||
| 3. Round | 12/09/2021 | Blois Foot 41 [Youth B] | - | Tours FC [Youth B] | 0:1 | ||||
| 6. Round | 03/10/2021 | Tours FC [Youth B] | - | SM Caen [Youth B] | 2:1 | ||||
| 7. Round | 10/10/2021 | AS Vitré [Youth B] | - | Tours FC [Youth B] | 3:1 | ||||
| 8. Round | 17/10/2021 | Tours FC [Youth B] | - | FC Rouen 1899 [Youth B] | 1:2 | ||||
| 12. Round | 28/11/2021 | US Avranches [Youth B] | - | Tours FC [Youth B] | 2:1 | ||||
| 17. Round | 12/02/2022 | Tours FC [Youth B] | - | Le Mans FC [Youth B] | 1:4 |
France