| 16. Round | 06/02/2022 | Angoulême CFC [Youth B] | - | USSA Vertou [Youth B] | 0:1 | ||||
| 20. Round | 20/03/2022 | Angoulême CFC [Youth B] | - | LB Châteauroux [Youth B] | 3:2 | ||||
| 21. Round | 27/03/2022 | SO Cholet [Youth B] | - | Angoulême CFC [Youth B] | 4:1 | ||||
| 23. Round | 10/04/2022 | Stade Rennais [Youth B] | - | Angoulême CFC [Youth B] | 2:0 | ||||
| 24. Round | 16/04/2022 | Angoulême CFC [Youth B] | - | Stade brestois 29 [Youth B] | 0:7 | ||||
| 26. Round | 15/05/2022 | Angoulême CFC [Youth B] | - | EA Guingamp [Youth B] | 1:4 |
France