| 1. Round | 29/08/2021 | FC Mantois [Youth B] | - | Tours FC [Youth B] | 2:0 | ||||
| 2. Round | 05/09/2021 | Tours FC [Youth B] | - | Havre AC [Youth B] | 0:5 | ||||
| 3. Round | 12/09/2021 | Blois Foot 41 [Youth B] | - | Tours FC [Youth B] | 0:1 | ||||
| 4. Round | 19/09/2021 | Tours FC [Youth B] | - | Paris Saint-Germain [Youth B] | 2:2 |  |
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| 6. Round | 03/10/2021 | Tours FC [Youth B] | - | SM Caen [Youth B] | 2:1 | |
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| 7. Round | 10/10/2021 | AS Vitré [Youth B] | - | Tours FC [Youth B] | 3:1 | ||||
| 9. Round | 24/10/2021 | Montrouge FC [Youth B] | - | Tours FC [Youth B] | 1:1 | ||||
| 10. Round | 14/11/2021 | Tours FC [Youth B] | - | Paris FC [Youth B] | 0:4 | ||||
| 13. Round | 05/12/2021 | Tours FC [Youth B] | - | CS Brétigny [Youth B] | 3:4 | ||||
| 14. Round | 16/01/2022 | Havre AC [Youth B] | - | Tours FC [Youth B] | 0:2 | ||||
| 15. Round | 23/01/2022 | Tours FC [Youth B] | - | Blois Foot 41 [Youth B] | 2:0 | ||||
| 17. Round | 12/02/2022 | Tours FC [Youth B] | - | Le Mans FC [Youth B] | 1:4 | ||||
| 18. Round | 06/03/2022 | SM Caen [Youth B] | - | Tours FC [Youth B] | 3:2 |
France