| 1. Round | 07/08/2021 | RC Grasse | - | Lyon-La Duchère | 1:0 | ||||
| 2. Round | 14/08/2021 | Lyon-La Duchère | - | Louhans-Cuiseaux | 1:3 | ||||
| 5. Round | 04/09/2021 | Lyon-La Duchère | - | AS Monaco B | 0:2 | ||||
| 6. Round | 11/09/2021 | FC Martigues | - | Lyon-La Duchère | 0:3 | ||||
| 9. Round | 09/10/2021 | Lyon-La Duchère | - | Étoile FC | 0:1 | ||||
| 11. Round | 06/11/2021 | Lyon-La Duchère | - | Aubagne FC | 1:1 | ||||
| 20. Round | 05/03/2022 | Lyon-La Duchère | - | FC Martigues | 2:2 | ||||
| 24. Round | 09/04/2022 | Lyon-La Duchère | - | GOAL FC | 1:0 | ||||
| 25. Round | 16/04/2022 | Aubagne FC | - | Lyon-La Duchère | 1:1 | ||||
| 27. Round | 30/04/2022 | Olympique Marseille B | - | Lyon-La Duchère | 2:1 | ||||
| 29. Round | 21/05/2022 | Olympique Lyonnais B | - | Lyon-La Duchère | 0:4 |
France
Gabon