| 3. Round | 20/08/2021 | FC Bourg-Péronnas | - | SO Cholet | 4:0 |  |
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| 4. Round | 27/08/2021 | SO Cholet | - | CS Sedan | 1:1 | ||||
| 5. Round | 03/09/2021 | Stade Lavallois | - | SO Cholet | 2:1 |  |
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| 6. Round | 10/09/2021 | SO Cholet | - | US Concarneau | 4:2 | |
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| 7. Round | 17/09/2021 | US Boulogne | - | SO Cholet | 2:3 | ||||
| 8. Round | 24/09/2021 | SO Cholet | - | FC Chambly | 2:0 | ||||
| 9. Round | 01/10/2021 | Red Star FC | - | SO Cholet | 4:2 | ||||
| 10. Round | 08/10/2021 | SO Cholet | - | US Orléans | 3:1 | ||||
| 11. Round | 22/10/2021 | FC Annecy | - | SO Cholet | 3:0 | ||||
| 12. Round | 26/10/2021 | SO Cholet | - | FC Villefranche Beaujolais | 3:4 | ||||
| 13. Round | 05/11/2021 | FC Bastia-Borgo | - | SO Cholet | 1:2 | ||||
| 14. Round | 19/11/2021 | Stade Briochin | - | SO Cholet | 1:1 | ||||
| 15. Round | 04/12/2021 | SO Cholet | - | US Avranches | 1:1 | |
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| 19. Round | 21/01/2022 | SO Cholet | - | FC Bourg-Péronnas | 2:1 | |
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| 16. Round | 25/01/2022 | Le Mans FC | - | SO Cholet | 1:0 | ||||
| 17. Round | 29/01/2022 | SO Cholet | - | US Créteil-Lusitanos | 3:2 | |
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| 20. Round | 04/02/2022 | CS Sedan | - | SO Cholet | 3:1 | ||||
| 21. Round | 12/02/2022 | SO Cholet | - | Stade Lavallois | 1:3 |
France
Haiti