| 1. Round | 05/08/2017 | Olympique Lyonnais | - | RC Strasbourg | 4:0 |  |
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| 2. Round | 13/08/2017 | RC Strasbourg | - | Lille OSC | 3:0 | ||||
| 3. Round | 19/08/2017 | Montpellier HSC | - | RC Strasbourg | 1:1 | |
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| 4. Round | 27/08/2017 | EA Guingamp | - | RC Strasbourg | 2:0 | ||||
| 5. Round | 09/09/2017 | RC Strasbourg | - | Amiens SC | 0:1 | ||||
| 9. Round | 15/10/2017 | RC Strasbourg | - | Olympique Marseille | 3:3 | ||||
| 10. Round | 22/10/2017 | OGC Nice | - | RC Strasbourg | 1:2 | ||||
| 11. Round | 28/10/2017 | RC Strasbourg | - | Angers SCO | 2:2 | ||||
| 12. Round | 04/11/2017 | ESTAC Troyes | - | RC Strasbourg | 3:0 | ||||
| 13. Round | 18/11/2017 | RC Strasbourg | - | Stade Rennais | 2:1 | ||||
| 14. Round | 24/11/2017 | AS Saint-Étienne | - | RC Strasbourg | 2:2 | ||||
| 17. Round | 08/12/2017 | Girondins Bordeaux | - | RC Strasbourg | 0:3 | ||||
| 28. Round | 04/03/2018 | SM Caen | - | RC Strasbourg | 2:0 | ||||
| 30. Round | 17/03/2018 | Toulouse FC | - | RC Strasbourg | 2:2 |
France