| 1. Round | 06/08/2010 | Vannes OC | - | ESTAC Troyes | 1:0 | ||||
| 2. Round | 13/08/2010 | Évian Thonon Gaillard | - | Vannes OC | 4:0 | ||||
| 3. Round | 17/08/2010 | Vannes OC | - | Stade Lavallois | 2:1 | ||||
| 4. Round | 20/08/2010 | FC Metz | - | Vannes OC | 1:0 | ||||
| 5. Round | 27/08/2010 | FC Nantes | - | Vannes OC | 2:0 |  |
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| 6. Round | 10/09/2010 | Vannes OC | - | Stade de Reims | 4:1 | ||||
| 7. Round | 17/09/2010 | AC Ajaccio | - | Vannes OC | 3:0 | ||||
| 8. Round | 24/09/2010 | Vannes OC | - | Tours FC | 0:0 | |
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| 9. Round | 01/10/2010 | Grenoble Foot 38 | - | Vannes OC | 1:2 | ||||
| 11. Round | 19/10/2010 | Dijon FCO | - | Vannes OC | 4:1 |  |
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| 12. Round | 22/10/2010 | Vannes OC | - | US Boulogne | 0:0 | ||||
| 13. Round | 29/10/2010 | CS Sedan | - | Vannes OC | 4:0 | ||||
| 14. Round | 05/11/2010 | Vannes OC | - | Clermont Foot Auvergne 63 | 1:1 | |
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| 15. Round | 12/11/2010 | FC Istres | - | Vannes OC | 3:0 | ||||
| 16. Round | 26/11/2010 | Vannes OC | - | Angers SCO | 0:0 | ||||
| 17. Round | 03/12/2010 | Nîmes Olympique | - | Vannes OC | 2:1 | |
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| 18. Round | 17/12/2010 | Vannes OC | - | Havre AC | 1:1 |  |
France