| 1. Round | 16/08/2021 | Giresunspor | - | Galatasaray | 0:2 | ||||
| 2. Round | 21/08/2021 | Kasımpaşa SK | - | Giresunspor | 2:0 | ||||
| 3. Round | 29/08/2021 | Giresunspor | - | Trabzonspor | 0:1 | ||||
| 7. Round | 26/09/2021 | Giresunspor | - | Kayserispor | 1:1 | ||||
| 8. Round | 02/10/2021 | Göztepe | - | Giresunspor | 0:1 |  |
|||
| 9. Round | 16/10/2021 | Giresunspor | - | Çaykur Rizespor | 2:0 | |
|||
| 10. Round | 23/10/2021 | Gaziantep FK | - | Giresunspor | 1:1 | ||||
| 11. Round | 01/11/2021 | Giresunspor | - | Antalyaspor | 1:2 | |
France