| Primera División | Matches | W | D | L |  |
 |
 |
| home | 4 | 1 | 2 | 1 | 7 | 1 | 1 |
| away | 5 | - | 2 | 3 | 12 | 3 | - |
| overall | 9 | 1 | 4 | 4 | 19 | 4 | 1 |
| Segunda División | Matches | W | D | L | |
|
|
| home | 2 | 1 | 1 | - | 8 | 1 | - |
| away | 1 | - | 1 | - | 3 | - | - |
| overall | 3 | 1 | 2 | - | 11 | 1 | - |
| Primera División | Home | - | Guest | |
|
|
Results |
| 18/10/19 | Montevideo Wanderers | - | Defensor Sporting | 1 | 1 | - | 2:0 |
| 27/08/20 | Defensor Sporting | - | CA Cerro | 1 | 1 | - | 1:1 |
| 01/02/21 | Defensor Sporting | - | River Plate | 3 | - | - | 0:2 |
| 09/04/22 | Cerro Largo | - | Defensor Sporting | 4 | - | - | 0:0 |
| 13/03/23 | Defensor Sporting | - | Liverpool | 2 | - | 1 | 2:2 |
| 18/10/23 | Liverpool | - | Defensor Sporting | 4 | 2 | - | 2:0 |
| 25/02/24 | Defensor Sporting | - | CA Cerro | 1 | - | - | 5:0 |
| 16/03/25 | Juventud de Las Piedras | - | Defensor Sporting | 2 | - | - | 2:1 |
| 18/06/25 | Montevideo Wanderers | - | Defensor Sporting | 1 | - | - | 0:0 |
| Segunda División | Home | - | Guest | |
|
|
Results |
| 11/06/21 | CA Cerro | - | Defensor Sporting | 3 | - | - | 0:0 |
| 12/10/21 | Defensor Sporting | - | Atenas | 5 | 1 | - | 1:1 |
| 10/11/21 | Defensor Sporting | - | Uruguay Montevideo | 3 | - | - | 2:0 |
Uruguay