| Primera División | Matches | W | D | L |  |
 |
 |
| home | 5 | - | 1 | 4 | 14 | - | 1 |
| away | 5 | 3 | 1 | 1 | 12 | 1 | - |
| overall | 10 | 3 | 2 | 5 | 26 | 1 | 1 |
| Segunda División | Matches | W | D | L | |
|
|
| home | 1 | 1 | - | - | 3 | - | - |
| away | - | - | - | - | - | - | - |
| overall | 1 | 1 | - | - | 3 | - | - |
| Primera División | Home | - | Guest | |
|
|
Results |
| 09/10/10 | Miramar Misiones | - | Defensor Sporting | 5 | - | - | 0:1 |
| 13/11/11 | Cerro Largo | - | Defensor Sporting | 1 | 1 | - | 0:3 |
| 17/03/13 | Defensor Sporting | - | Progreso | 4 | - | - | 0:1 |
| 28/09/14 | Tacuarembó | - | Defensor Sporting | 3 | - | - | 1:4 |
| 07/06/15 | Rampla Juniors | - | Defensor Sporting | 1 | - | - | 0:0 |
| 04/09/16 | Defensor Sporting | - | Juventud de Las Piedras | 2 | - | 1 | 0:1 |
| 12/08/18 | Defensor Sporting | - | Rampla Juniors | 3 | - | - | 2:2 |
| 22/11/20 | Defensor Sporting | - | Fénix | 4 | - | - | 0:1 |
| 22/10/22 | Defensor Sporting | - | Rentistas | 1 | - | - | 2:3 |
| 16/04/23 | Boston River | - | Defensor Sporting | 2 | - | - | 1:0 |
| Segunda División | Home | - | Guest | |
|
|
Results |
| 03/06/21 | Defensor Sporting | - | Rocha | 3 | - | - | 2:1 |
Uruguay