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| 1st(1st leg) | Almirante Brown | - | Barracas Central | 0:0 (0:0) | ||
| 2nd (2nd leg) | Barracas Central | - | Almirante Brown | 3:2 (3:0) | ||
| 1st(1st leg): 06/12/2021 20:00 | 2nd (2nd leg): 13/12/2021 20:00 | Winner: Barracas Central | ||||
| 1st(1st leg) | Ferro Carril Oeste | - | Quilmes | 1:1 (0:0) | ||
| 2nd (2nd leg) | Quilmes | - | Ferro Carril Oeste | 1:0 (0:0) | ||
| 1st(1st leg): 07/12/2021 00:10 | 2nd (2nd leg): 14/12/2021 00:10 | Winner: Quilmes | ||||
