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| 1st(1st leg) | Sol de Mayo de Viedma | - | Huracán de Las Heras | 1:0 (1:0) | ||
| 2nd (2nd leg) | Huracán de Las Heras | - | Sol de Mayo de Viedma | 1:2 (0:0) | ||
| 1st(1st leg): 28/04/2019 19:30 | 2nd (2nd leg): 05/05/2019 20:00 | Winner: Sol de Mayo de Viedma | ||||
| 1st(1st leg) | Deportivo Madryn | - | Chaco For Ever | 1:0 (1:0) | ||
| 2nd (2nd leg) | Chaco For Ever | - | Deportivo Madryn | 0:0 (0:0) | ||
| 1st(1st leg): 28/04/2019 20:00 | 2nd (2nd leg): 05/05/2019 20:00 | Winner: Deportivo Madryn | ||||
| 1st(1st leg) | Deportivo Maipú | - | Desamparados de San Juan | 1:0 (0:0) | ||
| 2nd (2nd leg) | Desamparados de San Juan | - | Deportivo Maipú | 3:1 (1:1) | ||
| 1st(1st leg): 28/04/2019 20:00 | 2nd (2nd leg): 05/05/2019 20:00 | Winner: Desamparados de San Juan | ||||
| 1st(1st leg) | Sportivo Las Parejas | - | Gimnasia y Esgrima (CdU) | 0:0 (0:0) | ||
| 2nd (2nd leg) | Gimnasia y Esgrima (CdU) | - | Sportivo Las Parejas | 1:0 (0:0) | ||
| 1st(1st leg): 30/04/2019 00:00 | 2nd (2nd leg): 05/05/2019 19:00 | Winner: Gimnasia y Esgrima (CdU) | ||||
