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| 17/04/2022 | 00:00 | Crucero del Norte | - | Belgrano de San Francisco | 1:0 (1:0) | |
| 19:30 | Defensores de Pronunciamiento | - | San Martín de Formosa | 0:1 (0:1) | ||
| 19:45 | Boca Unidos | - | Gimnasia y Esgrima (CdU) | 0:0 (0:0) | ||
| 20:00 | Gimnasia y Tiro de Salta | - | Defensores Belgrano (VR) | 2:0 (0:0) | ||
| 20:00 | Unión de Sunchales | - | Central Norte | 0:0 (0:0) | ||
| 20:30 | Juventud Antoniana | - | Racing de Córdoba | 0:4 (0:2) | ||
| 20:30 | Sportivo Las Parejas | - | Sarmiento de Resistencia | 0:1 (0:0) | ||
| 23:00 | Atlético Paraná | - | Douglas Haig | 1:0 (1:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 4 | 3 | 1 | 0 | 10:1 | 9 | 10 |
| 2 |
|
Sarmiento de Resistencia | 4 | 3 | 1 | 0 | 4:0 | 4 | 10 |
| 3 |
|
Douglas Haig | 4 | 3 | 0 | 1 | 8:2 | 6 | 9 |
| 4 |
|
Crucero del Norte | 4 | 3 | 0 | 1 | 5:4 | 1 | 9 |
| 5 |
|
San Martín de Formosa | 3 | 2 | 1 | 0 | 3:1 | 2 | 7 |
| 6 |
|
Gimnasia y Tiro de Salta | 4 | 2 | 0 | 2 | 3:5 | -2 | 6 |
| 7 |
|
Boca Unidos | 3 | 1 | 2 | 0 | 2:1 | 1 | 5 |
| 8 |
|
Central Norte | 3 | 1 | 2 | 0 | 1:0 | 1 | 5 |
| 9 |
|
Gimnasia y Esgrima (CdU) | 4 | 1 | 2 | 1 | 3:4 | -1 | 5 |
| 10 |
|
Juventud Antoniana | 4 | 1 | 2 | 1 | 2:5 | -3 | 5 |
| 11 |
|
Belgrano de San Francisco | 4 | 1 | 1 | 2 | 3:4 | -1 | 4 |
| 12 |
|
Atlético Paraná | 4 | 1 | 1 | 2 | 1:3 | -2 | 4 |
| 13 |
|
Sportivo Las Parejas | 4 | 0 | 2 | 2 | 3:5 | -2 | 2 |
| 14 |
|
Defensores Belgrano (VR) | 4 | 0 | 2 | 2 | 2:5 | -3 | 2 |
| 15 |
|
Unión de Sunchales | 4 | 0 | 2 | 2 | 1:4 | -3 | 2 |
| 16 |
|
Defensores de Pronunciamiento | 4 | 0 | 1 | 3 | 1:5 | -4 | 1 |
| 17 |
|
Juventud Unida de Gualeguaychú | 3 | 0 | 0 | 3 | 1:4 | -3 | 0 |
| Playoffs |
