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| 1st(1st leg) | Floresta - CE | - | América - RN | 2:0 (1:0) | ||
| 2nd (2nd leg) | América - RN | - | Floresta - CE | 1:1 (1:0) | ||
| 1st(1st leg): 02/01/2021 19:00 | 2nd (2nd leg): 10/01/2021 19:00 | Winner: Floresta - CE | ||||
| 1st(1st leg) | Mirassol - SP | - | Aparecidense - GO | 2:1 (0:1) | ||
| 2nd (2nd leg) | Aparecidense - GO | - | Mirassol - SP | 2:3 (1:0) | ||
| 1st(1st leg): 02/01/2021 22:00 | 2nd (2nd leg): 09/01/2021 19:00 | Winner: Mirassol - SP | ||||
| 1st(1st leg) | Marcílio Dias - SC | - | Altos - PI | 1:1 (0:0) | ||
| 2nd (2nd leg) | Altos - PI | - | Marcílio Dias - SC | 5:1 (1:0) | ||
| 1st(1st leg): 03/01/2021 19:00 | 2nd (2nd leg): 10/01/2021 18:45 | Winner: Altos - PI | ||||
| 1st(1st leg) | Fast Clube - AM | - | Grêmio Novorizontino - SP | 0:1 (0:1) | ||
| 2nd (2nd leg) | Grêmio Novorizontino - SP | - | Fast Clube - AM | 3:0 (3:0) | ||
| 1st(1st leg): 03/01/2021 19:00 | 2nd (2nd leg): 10/01/2021 19:00 | Winner: Grêmio Novorizontino - SP | ||||
