1st(1st leg) Floresta - CE - América - RN 2:0 (1:0)
2nd (2nd leg) América - RN - Floresta - CE 1:1
1st(1st leg): 02/01/2021 19:00 2nd (2nd leg): 10/01/2021 19:00 Winner: Floresta - CE
1st(1st leg) Mirassol - SP - Aparecidense - GO 2:1 (0:1)
2nd (2nd leg) Aparecidense - GO - Mirassol - SP 2:3
1st(1st leg): 02/01/2021 22:00 2nd (2nd leg): 09/01/2021 19:00 Winner: Mirassol - SP
1st(1st leg) Marcílio Dias - SC - Altos - PI 1:1
2nd (2nd leg) Altos - PI - Marcílio Dias - SC 5:1
1st(1st leg): 03/01/2021 19:00 2nd (2nd leg): 10/01/2021 18:45 Winner: Altos - PI
1st(1st leg) Fast Clube - AM - Grêmio Novorizontino - SP 0:1
2nd (2nd leg) Grêmio Novorizontino - SP - Fast Clube - AM 3:0
1st(1st leg): 03/01/2021 19:00 2nd (2nd leg): 10/01/2021 19:00 Winner: Grêmio Novorizontino - SP