1st(1st leg) Espérance de Tunis - Zanaco FC 2:0
2nd (2nd leg) Zanaco FC - Espérance de Tunis 1:4
1st(1st leg): 02/03/2007 2nd (2nd leg): 17/03/2007 Winner: Espérance de Tunis
1st(1st leg) Nasarawa United - Ports Authority FC 3:0
2nd (2nd leg) Ports Authority FC - Nasarawa United 2:1
1st(1st leg): 03/03/2007 2nd (2nd leg): 17/03/2007 Winner: Nasarawa United
1st(1st leg) APR FC - Maranatha FC 2:0
2nd (2nd leg) Maranatha FC - APR FC abor.
1st(1st leg): 03/03/2007 2nd (2nd leg): 17/03/2007
1st(1st leg) Séwé Sport - Coton Sport Garoua 1:0
2nd (2nd leg) Coton Sport Garoua - Séwé Sport 4:0
1st(1st leg): 03/03/2007 2nd (2nd leg): 18/03/2007 Winner: Coton Sport Garoua
1st(1st leg) Highlanders FC - Al Ahly SC 0:0
2nd (2nd leg) Al Ahly SC - Highlanders FC 2:0
1st(1st leg): 04/03/2007 2nd (2nd leg): 18/03/2007 Winner: Al Ahly SC
1st(1st leg) GD Maputo - Mamelodi Sundowns 1:1
2nd (2nd leg) Mamelodi Sundowns - GD Maputo 2:0
1st(1st leg): 04/03/2007 2nd (2nd leg): 17/03/2007 Winner: Mamelodi Sundowns
1st(1st leg) Al Hilal Omdurman - Zamalek 2:0
2nd (2nd leg) Zamalek - Al Hilal Omdurman 2:2
1st(1st leg): 04/03/2007 2nd (2nd leg): 17/03/2007 Winner: Al Hilal Omdurman
1st(1st leg) St. George SC - Etoile du Congo 1:0
2nd (2nd leg) Etoile du Congo - St. George SC 2:0
1st(1st leg): 04/03/2007 2nd (2nd leg): 18/03/2007 Winner: Etoile du Congo
1st(1st leg) Stade Malien - Wydad AC 0:0
2nd (2nd leg) Wydad AC - Stade Malien 3:1
1st(1st leg): 04/03/2007 2nd (2nd leg): 18/03/2007 Winner: Wydad AC
1st(1st leg) Kallon FC - ASEC Mimosas 0:1
2nd (2nd leg) ASEC Mimosas - Kallon FC 2:1
1st(1st leg): 04/03/2007 2nd (2nd leg): 18/03/2007 Winner: ASEC Mimosas
1st(1st leg) Young Africans - Petro Atlético 3:0
2nd (2nd leg) Petro Atlético - Young Africans 2:0
1st(1st leg): 04/03/2007 2nd (2nd leg): 17/03/2007 Winner: Young Africans
1st(1st leg) Ashanti Gold - FAR de Rabat 2:0
2nd (2nd leg) FAR de Rabat - Ashanti Gold 7:6 pso
1st(1st leg): 04/03/2007 2nd (2nd leg): 17/03/2007 Winner: FAR de Rabat
1st(1st leg) AS Adema - TP Mazembe 2:2
2nd (2nd leg) TP Mazembe - AS Adema 4:1
1st(1st leg): 04/03/2007 2nd (2nd leg): 17/03/2007 Winner: TP Mazembe
1st(1st leg) Mangasport Moanda - JS Kabylie 3:1
2nd (2nd leg) JS Kabylie - Mangasport Moanda 3:0
1st(1st leg): 04/03/2007 2nd (2nd leg): 16/03/2007 Winner: JS Kabylie
1st(1st leg) Al Ittihad Tripolis - AS FNIS 4:1
2nd (2nd leg) AS FNIS - Al Ittihad Tripolis 0:1
1st(1st leg): 05/03/2007 2nd (2nd leg): 17/03/2007 Winner: Al Ittihad Tripolis
1st(1st leg) Fello Star - Étoile du Sahel 0:1
2nd (2nd leg) Étoile du Sahel - Fello Star 4:1
1st(1st leg): 11/03/2007 2nd (2nd leg): 17/03/2007 Winner: Étoile du Sahel