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| 1st(1st leg) | TP Mazembe | - | JS Kabylie | 3:1 (1:0) | ||
| 2nd (2nd leg) | JS Kabylie | - | TP Mazembe | 0:0 (0:0) | ||
| 1st(1st leg): 03/10/2010 14:30 | 2nd (2nd leg): 16/10/2010 20:15 | Winner: TP Mazembe | ||||
| 1st(1st leg) | Al Ahly SC | - | Espérance de Tunis | 2:1 (1:0) | ||
| 2nd (2nd leg) | Espérance de Tunis | - | Al Ahly SC | 1:0 (1:0) | ||
| 1st(1st leg): 03/10/2010 18:30 | 2nd (2nd leg): 17/10/2010 19:30 | Winner: Espérance de Tunis | ||||
