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| 1st(1st leg) | Coin Nord Mitsamiouli | - | Clube Ferroviário Maputo | 3:5 | ||
| 2nd (2nd leg) | Clube Ferroviário Maputo | - | Coin Nord Mitsamiouli | 4:1 | ||
| 1st(1st leg): 12/02/2010 | 2nd (2nd leg): 27/02/2010 | Winner: Clube Ferroviário Maputo | ||||
| 1st(1st leg) | APR FC | - | CRD Libolo | 2:2 | ||
| 2nd (2nd leg) | CRD Libolo | - | APR FC | 0:1 | ||
| 1st(1st leg): 13/02/2010 | 2nd (2nd leg): 27/02/2010 | Winner: APR FC | ||||
| 1st(1st leg) | ASC Linguère | - | Asante Kotoko | 2:0 | ||
| 2nd (2nd leg) | Asante Kotoko | - | ASC Linguère | 2:4 pso | ||
| 1st(1st leg): 13/02/2010 | 2nd (2nd leg): 28/02/2010 | Winner: ASC Linguère | ||||
| 1st(1st leg) | Sofapaka FC | - | Ismaily | 0:0 | ||
| 2nd (2nd leg) | Ismaily | - | Sofapaka FC | 2:0 | ||
| 1st(1st leg): 13/02/2010 | 2nd (2nd leg): 27/02/2010 | Winner: Ismaily | ||||
| 1st(1st leg) | US Stade Tamponnaise | - | Ajesaia | 2:1 | ||
| 2nd (2nd leg) | Ajesaia | - | US Stade Tamponnaise | 1:3 | ||
| 1st(1st leg): 13/02/2010 | 2nd (2nd leg): 28/02/2010 | Winner: US Stade Tamponnaise | ||||
| 1st(1st leg) | Armed Forces | - | JS Kabylie | 1:2 | ||
| 2nd (2nd leg) | JS Kabylie | - | Armed Forces | 3:0 | ||
| 1st(1st leg): 13/02/2010 | 2nd (2nd leg): 27/02/2010 | Winner: JS Kabylie | ||||
| 1st(1st leg) | East End Lions | - | Espérance de Tunis | 2:2 | ||
| 2nd (2nd leg) | Espérance de Tunis | - | East End Lions | 3:2 | ||
| 1st(1st leg): 13/02/2010 | 2nd (2nd leg): 26/02/2010 | Winner: Espérance de Tunis | ||||
| 1st(1st leg) | Gaborone United | - | Orlando Pirates | 0:0 | ||
| 2nd (2nd leg) | Orlando Pirates | - | Gaborone United | 2:2 | ||
| 1st(1st leg): 13/02/2010 | 2nd (2nd leg): 28/02/2010 | Winner: Gaborone United | ||||
| 1st(1st leg) | Young Africans | - | FC St. Eloi Lupopo | 2:3 | ||
| 2nd (2nd leg) | FC St. Eloi Lupopo | - | Young Africans | 1:0 | ||
| 1st(1st leg): 13/02/2010 | 2nd (2nd leg): 27/02/2010 | Winner: FC St. Eloi Lupopo | ||||
| 1st(1st leg) | CF Os Balantas Mansoa | - | Difaâ d'el Jadida | 0:0 | ||
| 2nd (2nd leg) | Difaâ d'el Jadida | - | CF Os Balantas Mansoa | 3:0 | ||
| 1st(1st leg): 13/02/2010 | 2nd (2nd leg): 27/02/2010 | Winner: Difaâ d'el Jadida | ||||
| 1st(1st leg) | Vital'O | - | Tiko United FC | 2:2 | ||
| 2nd (2nd leg) | Tiko United FC | - | Vital'O | 5:3 pso | ||
| 1st(1st leg): 13/02/2010 | 2nd (2nd leg): 27/02/2010 | Winner: Tiko United FC | ||||
| 1st(1st leg) | Djoliba AC | - | Al Ahly Benghazi | 1:0 | ||
| 2nd (2nd leg) | Al Ahly Benghazi | - | Djoliba AC | 0:0 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 28/02/2010 | Winner: Djoliba AC | ||||
| 1st(1st leg) | Fello Star | - | Raja Casablanca | 1:3 | ||
| 2nd (2nd leg) | Raja Casablanca | - | Fello Star | 1:1 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 28/02/2010 | Winner: Raja Casablanca | ||||
| 1st(1st leg) | Sony de Elá Nguema | - | Petro Atlético | 2:3 | ||
| 2nd (2nd leg) | Petro Atlético | - | Sony de Elá Nguema | 6:1 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 28/02/2010 | Winner: Petro Atlético | ||||
| 1st(1st leg) | Sahel SC | - | Club Africain | 2:1 | ||
| 2nd (2nd leg) | Club Africain | - | Sahel SC | 1:0 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 26/02/2010 | Winner: Club Africain | ||||
| 1st(1st leg) | Gazelle FC | - | Bayelsa United | 1:0 | ||
| 2nd (2nd leg) | Bayelsa United | - | Gazelle FC | 2:2 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 28/02/2010 | Winner: Gazelle FC | ||||
| 1st(1st leg) | St. George SC | - | Al Merrikh SC | 1:1 | ||
| 2nd (2nd leg) | Al Merrikh SC | - | St. George SC | 3:1 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 27/02/2010 | Winner: Al Merrikh SC | ||||
| 1st(1st leg) | AS Stade Mandji | - | ASFA Yennenga | 0:2 | ||
| 2nd (2nd leg) | ASFA Yennenga | - | AS Stade Mandji | 4:1 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 28/02/2010 | Winner: ASFA Yennenga | ||||
| 1st(1st leg) | La Passe FC | - | Curepipe Starlight SC | 1:0 | ||
| 2nd (2nd leg) | Curepipe Starlight SC | - | La Passe FC | 3:1 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 28/02/2010 | Winner: Curepipe Starlight SC | ||||
| 1st(1st leg) | Mafunzo | - | Gunners FC | 1:2 | ||
| 2nd (2nd leg) | Gunners FC | - | Mafunzo | 4:0 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 28/02/2010 | Winner: Gunners FC | ||||
| 1st(1st leg) | AS Tempête Mocaf | - | Al Ittihad Tripolis | 1:2 | ||
| 2nd (2nd leg) | Al Ittihad Tripolis | - | AS Tempête Mocaf | 6:0 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 27/02/2010 | Winner: Al Ittihad Tripolis | ||||
| 1st(1st leg) | URA SC | - | Zanaco FC | 1:0 | ||
| 2nd (2nd leg) | Zanaco FC | - | URA SC | 4:0 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 27/02/2010 | Winner: Zanaco FC | ||||
| 1st(1st leg) | Diables Noirs | - | ES Sétif | 3:2 | ||
| 2nd (2nd leg) | ES Sétif | - | Diables Noirs | 2:0 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 27/02/2010 | Winner: ES Sétif | ||||
| 1st(1st leg) | Mbabane Swallows | - | SuperSport United | 1:3 | ||
| 2nd (2nd leg) | SuperSport United | - | Mbabane Swallows | 2:2 | ||
| 1st(1st leg): 14/02/2010 | 2nd (2nd leg): 27/02/2010 | Winner: SuperSport United | ||||
