1st(1st leg) MC Alger / Wydad AC - Kaizer Chiefs / Simba -:-
2nd (2nd leg) Kaizer Chiefs / Simba - MC Alger / Wydad AC -:-
1st(1st leg): 18/06/2021 2nd (2nd leg): 25/06/2021
1st(1st leg) Belouizdad / Esperance - Al Ahly / Mamelodi Sundowns -:-
2nd (2nd leg) Al Ahly / Mamelodi Sundowns - Belouizdad / Esperance -:-
1st(1st leg): 18/06/2021 2nd (2nd leg): 25/06/2021