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| 1st(1st leg) | Espérance de Tunis | - | Al Ahly SC | 0:1 (0:0) | ||
| 2nd (2nd leg) | Al Ahly SC | - | Espérance de Tunis | 3:0 (1:0) | ||
| 1st(1st leg): 19/06/2021 17:00 | 2nd (2nd leg): 26/06/2021 20:00 | Winner: Al Ahly SC | ||||
| 1st(1st leg) | Wydad AC | - | Kaizer Chiefs | 0:1 (0:1) | ||
| 2nd (2nd leg) | Kaizer Chiefs | - | Wydad AC | 0:0 (0:0) | ||
| 1st(1st leg): 19/06/2021 20:00 | 2nd (2nd leg): 26/06/2021 17:00 | Winner: Kaizer Chiefs | ||||
