1st(1st leg) MC Alger - Wydad AC -:-
2nd (2nd leg) Wydad AC - MC Alger -:-
1st(1st leg): 14/05/2021 20:00 2nd (2nd leg): 22/05/2021 17:00
1st(1st leg) CR Bélouizdad - Espérance de Tunis -:-
2nd (2nd leg) Espérance de Tunis - CR Bélouizdad -:-
1st(1st leg): 15/05/2021 17:00 2nd (2nd leg): 22/05/2021 17:00
1st(1st leg) Kaizer Chiefs - Simba SC -:-
2nd (2nd leg) Simba SC - Kaizer Chiefs -:-
1st(1st leg): 15/05/2021 17:00 2nd (2nd leg): 22/05/2021 14:00
1st(1st leg) Al-Ahly - Mamelodi Sundowns -:-
2nd (2nd leg) Mamelodi Sundowns - Al-Ahly -:-
1st(1st leg): 15/05/2021 20:00 2nd (2nd leg): 22/05/2021 14:00