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| 1st(1st leg) | Al Merrikh SC | - | Al Ahly Tripolis | 2:0 (2:0) | ||
| 2nd (2nd leg) | Al Ahly Tripolis | - | Al Merrikh SC | 3:1 (2:1) | ||
| 1st(1st leg): 07/10/2022 15:00 | 2nd (2nd leg): 15/10/2022 18:00 | Winner: Al Merrikh SC | ||||
| 1st(1st leg) | Young Africans | - | Al Hilal Omdurman | 1:1 (0:0) | ||
| 2nd (2nd leg) | Al Hilal Omdurman | - | Young Africans | 1:0 (1:0) | ||
| 1st(1st leg): 08/10/2022 14:00 | 2nd (2nd leg): 16/10/2022 19:00 | Winner: Al Hilal Omdurman | ||||
| 1st(1st leg) | ASKO Kara | - | JS Kabylie | 1:2 (0:2) | ||
| 2nd (2nd leg) | JS Kabylie | - | ASKO Kara | 1:1 (1:0) | ||
| 1st(1st leg): 08/10/2022 16:00 | 2nd (2nd leg): 15/10/2022 19:00 | Winner: JS Kabylie | ||||
| 1st(1st leg) | ASN Nigelec | - | Raja Casablanca | 0:2 (0:0) | ||
| 2nd (2nd leg) | Raja Casablanca | - | ASN Nigelec | 1:0 (0:0) | ||
| 1st(1st leg): 08/10/2022 16:30 | 2nd (2nd leg): 15/10/2022 18:00 | Winner: Raja Casablanca | ||||
| 1st(1st leg) | Cape Town City FC | - | Petro Atlético | 0:3 (0:1) | ||
| 2nd (2nd leg) | Petro Atlético | - | Cape Town City FC | 1:0 (0:0) | ||
| 1st(1st leg): 08/10/2022 17:00 | 2nd (2nd leg): 14/10/2022 16:00 | Winner: Petro Atlético | ||||
| 1st(1st leg) | Vipers SC | - | TP Mazembe | 0:0 (0:0) | ||
| 2nd (2nd leg) | TP Mazembe | - | Vipers SC | 2:4 (0:0, 0:0) pso | ||
| 1st(1st leg): 09/10/2022 14:00 | 2nd (2nd leg): 15/10/2022 14:00 | Winner: Vipers SC | ||||
| 1st(1st leg) | Royal Leopards | - | Coton Sport Garoua | 1:1 (1:1) | ||
| 2nd (2nd leg) | Coton Sport Garoua | - | Royal Leopards | 2:1 (2:0) | ||
| 1st(1st leg): 09/10/2022 14:00 | 2nd (2nd leg): 16/10/2022 18:00 | Winner: Coton Sport Garoua | ||||
| 1st(1st leg) | US Monastir | - | Al Ahly SC | 0:1 (0:0) | ||
| 2nd (2nd leg) | Al Ahly SC | - | US Monastir | 3:0 (2:0) | ||
| 1st(1st leg): 09/10/2022 15:00 | 2nd (2nd leg): 15/10/2022 17:00 | Winner: Al Ahly SC | ||||
| 1st(1st leg) | La Passe FC | - | Mamelodi Sundowns | 0:7 (0:5) | ||
| 2nd (2nd leg) | Mamelodi Sundowns | - | La Passe FC | 8:1 (3:1) | ||
| 1st(1st leg): 09/10/2022 15:00 | 2nd (2nd leg): 14/10/2022 17:00 | Winner: Mamelodi Sundowns | ||||
| 1st(1st leg) | Rivers United | - | Wydad AC | 2:1 (1:1) | ||
| 2nd (2nd leg) | Wydad AC | - | Rivers United | 6:0 (2:0) | ||
| 1st(1st leg): 09/10/2022 16:00 | 2nd (2nd leg): 16/10/2022 20:00 | Winner: Wydad AC | ||||
| 1st(1st leg) | Plateau United | - | Espérance de Tunis | 2:1 (2:1) | ||
| 2nd (2nd leg) | Espérance de Tunis | - | Plateau United | 1:0 (0:0) | ||
| 1st(1st leg): 09/10/2022 16:00 | 2nd (2nd leg): 15/10/2022 17:00 | Winner: Espérance de Tunis | ||||
| 1st(1st leg) | CD 1º de Agosto | - | Simba SC | 1:3 (0:1) | ||
| 2nd (2nd leg) | Simba SC | - | CD 1º de Agosto | 1:0 (1:0) | ||
| 1st(1st leg): 09/10/2022 16:00 | 2nd (2nd leg): 16/10/2022 14:00 | Winner: Simba SC | ||||
| 1st(1st leg) | ASEC Mimosas | - | Horoya AC | 0:1 (0:0) | ||
| 2nd (2nd leg) | Horoya AC | - | ASEC Mimosas | 1:1 (0:0) | ||
| 1st(1st leg): 09/10/2022 17:00 | 2nd (2nd leg): 16/10/2022 17:00 | Winner: Horoya AC | ||||
| 1st(1st leg) | Djoliba AC | - | CR Bélouizdad | 2:1 (1:1) | ||
| 2nd (2nd leg) | CR Bélouizdad | - | Djoliba AC | 2:0 (1:0) | ||
| 1st(1st leg): 09/10/2022 17:00 | 2nd (2nd leg): 14/10/2022 19:30 | Winner: CR Bélouizdad | ||||
| 1st(1st leg) | Flambeau du Centre | - | Zamalek | 0:1 (0:1) | ||
| 2nd (2nd leg) | Zamalek | - | Flambeau du Centre | 5:1 (3:1) | ||
| 1st(1st leg): 09/10/2022 18:00 | 2nd (2nd leg): 14/10/2022 18:00 | Winner: Zamalek | ||||
| 1st(1st leg) | RC Kadiogo | - | AS Vita Club | 0:0 (0:0) | ||
| 2nd (2nd leg) | AS Vita Club | - | RC Kadiogo | 4:3 (0:0, 0:0) pso | ||
| 1st(1st leg): 16/10/2022 15:00 | 2nd (2nd leg): 20/10/2022 15:30 | Winner: AS Vita Club | ||||
