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| 1st(1st leg) | Club Olimpia | - | Grêmio Porto Alegre | 2:3 (2:1) | ||
| 2nd (2nd leg) | Grêmio Porto Alegre | - | Club Olimpia | 3:0 (2:0) | ||
| 1st(1st leg): 23/04/2003 01:10 | 2nd (2nd leg): 09/05/2003 01:40 | Winner: Grêmio Porto Alegre | ||||
| 1st(1st leg) | Cerro Porteño | - | Independiente Medellín | 0:1 (0:1) | ||
| 2nd (2nd leg) | Independiente Medellín | - | Cerro Porteño | 4:2 (0:0, 0:1, 0:1) pso | ||
| 1st(1st leg): 23/04/2003 23:10 | 2nd (2nd leg): 07/05/2003 00:10 | Winner: Independiente Medellín | ||||
| 1st(1st leg) | Nacional | - | Santos FC | 4:4 (0:2) | ||
| 2nd (2nd leg) | Santos FC | - | Nacional | 2:2 (1:2) | ||
| 1st(1st leg): 24/04/2003 01:40 | 2nd (2nd leg): 08/05/2003 01:40 | Winner: Santos FC | ||||
| 1st(1st leg) | Boca Juniors | - | Paysandu - PA | 0:1 (0:0) | ||
| 2nd (2nd leg) | Paysandu - PA | - | Boca Juniors | 2:4 (0:1) | ||
| 1st(1st leg): 25/04/2003 01:10 | 2nd (2nd leg): 16/05/2003 01:40 | Winner: Boca Juniors | ||||
| 1st(1st leg) | Pumas UNAM | - | Cobreloa | 0:1 (0:0) | ||
| 2nd (2nd leg) | Cobreloa | - | Pumas UNAM | 0:0 (0:0) | ||
| 1st(1st leg): 25/04/2003 03:30 | 2nd (2nd leg): 08/05/2003 23:10 | Winner: Cobreloa | ||||
| 1st(1st leg) | América de Cali | - | Racing Club | 1:1 (1:0) | ||
| 2nd (2nd leg) | Racing Club | - | América de Cali | 5:6 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 30/04/2003 01:40 | 2nd (2nd leg): 14/05/2003 00:10 | Winner: América de Cali | ||||
| 1st(1st leg) | River Plate | - | Corinthians SP | 2:1 (0:0) | ||
| 2nd (2nd leg) | Corinthians SP | - | River Plate | 1:2 (1:1) | ||
| 1st(1st leg): 01/05/2003 19:30 | 2nd (2nd leg): 15/05/2003 01:40 | Winner: River Plate | ||||
| 1st(1st leg) | Cruz Azul | - | Deportivo Cali | 0:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo Cali | - | Cruz Azul | 2:3 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 06/05/2003 23:40 | 2nd (2nd leg): 14/05/2003 01:40 | Winner: Cruz Azul | ||||
