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| 1st(1st leg) | Deportivo Guadalajara | - | Libertad | 3:0 (2:0) | ||
| 2nd (2nd leg) | Libertad | - | Deportivo Guadalajara | 2:0 (1:0) | ||
| 1st(1st leg): 12/05/2010 02:15 | 2nd (2nd leg): 19/05/2010 02:15 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Flamengo RJ | - | Universidad de Chile | 2:3 (1:2) | ||
| 2nd (2nd leg) | Universidad de Chile | - | Flamengo RJ | 1:2 (0:1) | ||
| 1st(1st leg): 12/05/2010 23:30 | 2nd (2nd leg): 21/05/2010 02:15 | Winner: Universidad de Chile | ||||
| 1st(1st leg) | Cruzeiro | - | São Paulo FC | 0:2 (0:1) | ||
| 2nd (2nd leg) | São Paulo FC | - | Cruzeiro | 2:0 (1:0) | ||
| 1st(1st leg): 13/05/2010 01:50 | 2nd (2nd leg): 20/05/2010 01:50 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Internacional | - | Estudiantes | 1:0 (0:0) | ||
| 2nd (2nd leg) | Estudiantes | - | Internacional | 2:1 (2:0) | ||
| 1st(1st leg): 14/05/2010 00:15 | 2nd (2nd leg): 20/05/2010 23:45 | Winner: Internacional | ||||
