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| 1st(1st leg) | River Plate | - | Universidad Católica | 2:0 (1:0) | ||
| 2nd (2nd leg) | Universidad Católica | - | River Plate | 4:0 (2:0) | ||
| 1st(1st leg): 30/07/2008 01:15 | 2nd (2nd leg): 08/08/2008 01:00 | Winner: Universidad Católica | ||||
| 1st(1st leg) | Universitario de Deportes | - | Deportivo Quito | 0:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo Quito | - | Universitario de Deportes | 2:1 (1:0) | ||
| 1st(1st leg): 31/07/2008 01:15 | 2nd (2nd leg): 05/08/2008 23:00 | Winner: Deportivo Quito | ||||
| 1st(1st leg) | UA Maracaibo | - | América de Cali | 0:0 (0:0) | ||
| 2nd (2nd leg) | América de Cali | - | UA Maracaibo | 4:2 (1:1) | ||
| 1st(1st leg): 01/08/2008 01:15 | 2nd (2nd leg): 08/08/2008 03:20 | Winner: América de Cali | ||||
| 1st(1st leg) | Club Olimpia | - | Blooming | 4:2 (4:0) | ||
| 2nd (2nd leg) | Blooming | - | Club Olimpia | 1:0 (0:0) | ||
| 1st(1st leg): 13/08/2008 02:30 | 2nd (2nd leg): 21/08/2008 23:00 | Winner: Club Olimpia | ||||
