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| 1st(1st leg) | Bella Vista | - | Universidad Católica | 1:1 (1:1) | ||
| 2nd (2nd leg) | Universidad Católica | - | Bella Vista | 3:0 (2:0) | ||
| 1st(1st leg): 02/08/2011 23:45 | 2nd (2nd leg): 17/08/2011 00:15 | Winner: Universidad Católica | ||||
| 1st(1st leg) | Universidad Cesar Vallejo | - | Santa Fe | 1:1 (1:0) | ||
| 2nd (2nd leg) | Santa Fe | - | Universidad Cesar Vallejo | 2:0 (0:0) | ||
| 1st(1st leg): 03/08/2011 02:00 | 2nd (2nd leg): 24/08/2011 02:45 | Winner: Santa Fe | ||||
| 1st(1st leg) | San José | - | Club Nacional | 0:0 (0:0) | ||
| 2nd (2nd leg) | Club Nacional | - | San José | 1:0 (1:0) | ||
| 1st(1st leg): 03/08/2011 23:00 | 2nd (2nd leg): 18/08/2011 02:00 | Winner: Club Nacional | ||||
| 1st(1st leg) | Deportivo Quito | - | Deportivo Anzoátegui | 1:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo Anzoátegui | - | Deportivo Quito | 2:0 (1:0) | ||
| 1st(1st leg): 03/08/2011 23:00 | 2nd (2nd leg): 17/08/2011 02:45 | Winner: Deportivo Anzoátegui | ||||
| 1st(1st leg) | Club Olimpia | - | The Strongest | 2:0 (0:0) | ||
| 2nd (2nd leg) | The Strongest | - | Club Olimpia | 2:1 (1:0) | ||
| 1st(1st leg): 04/08/2011 01:15 | 2nd (2nd leg): 11/08/2011 23:30 | Winner: Club Olimpia | ||||
| 1st(1st leg) | Yaracuyanos FC | - | LDU Quito | 1:1 (0:0) | ||
| 2nd (2nd leg) | LDU Quito | - | Yaracuyanos FC | 1:0 (1:0) | ||
| 1st(1st leg): 05/08/2011 01:15 | 2nd (2nd leg): 17/08/2011 23:00 | Winner: LDU Quito | ||||
| 1st(1st leg) | Universidad de Chile | - | Fénix | 1:0 (0:0) | ||
| 2nd (2nd leg) | Fénix | - | Universidad de Chile | 0:0 (0:0) | ||
| 1st(1st leg): 10/08/2011 02:00 | 2nd (2nd leg): 18/08/2011 23:15 | Winner: Universidad de Chile | ||||
| 1st(1st leg) | La Equidad | - | Juan Aurich | 2:0 (1:0) | ||
| 2nd (2nd leg) | Juan Aurich | - | La Equidad | 1:2 (1:0) | ||
| 1st(1st leg): 19/08/2011 01:45 | 2nd (2nd leg): 26/08/2011 02:45 | Winner: La Equidad | ||||
