1st(1st leg) Deportes Tolima - Sportivo Luqueño 1:1 (1:0)
2nd (2nd leg) Sportivo Luqueño - Deportes Tolima 1:0 (0:0)
1st(1st leg): 23/09/2015 01:00 2nd (2nd leg): 29/09/2015 23:00 Winner: Sportivo Luqueño
1st(1st leg) River Plate - LDU Quito 2:0 (1:0)
2nd (2nd leg) LDU Quito - River Plate 1:0 (0:0)
1st(1st leg): 23/09/2015 23:00 2nd (2nd leg): 30/09/2015 23:45 Winner: River Plate
1st(1st leg) Emelec - Santa Fe 2:1 (0:1)
2nd (2nd leg) Santa Fe - Emelec 1:0 (1:0)
1st(1st leg): 23/09/2015 23:00 2nd (2nd leg): 30/09/2015 01:00 Winner: Santa Fe
1st(1st leg) Independiente - Club Olimpia 1:0 (1:0)
2nd (2nd leg) Club Olimpia - Independiente 0:0 (0:0)
1st(1st leg): 24/09/2015 01:15 2nd (2nd leg): 01/10/2015 01:00 Winner: Independiente
1st(1st leg) Athletico Paranaense - Brasília FC 1:0 (0:0)
2nd (2nd leg) Brasília FC - Athletico Paranaense 0:0 (0:0)
1st(1st leg): 24/09/2015 02:00 2nd (2nd leg): 01/10/2015 02:00 Winner: Athletico Paranaense
1st(1st leg) Sport - PE - Huracán 1:1 (0:0)
2nd (2nd leg) Huracán - Sport - PE 3:0 (0:0)
1st(1st leg): 24/09/2015 02:00 2nd (2nd leg): 01/10/2015 02:10 Winner: Huracán
1st(1st leg) Lanús - Defensor Sporting 0:0 (0:0)
2nd (2nd leg) Defensor Sporting - Lanús 5:3 (0:0, 0:0) pso
1st(1st leg): 25/09/2015 01:00 2nd (2nd leg): 02/10/2015 01:00 Winner: Defensor Sporting
1st(1st leg) Libertad - Chapecoense 1:1 (0:1)
2nd (2nd leg) Chapecoense - Libertad 5:3 (1:1, 1:1) pso
1st(1st leg): 25/09/2015 01:00 2nd (2nd leg): 02/10/2015 01:00 Winner: Chapecoense