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| 13/09/2022 | 16:00 | Sporting Gijón | - | Córdoba CF | 0:1 | |
| 17:30 | CA Osasuna | - | AEM Llleida | 1:0 | ||
| 18:00 | CD Pradejón | - | Espanyol Barcelona | 1:3 | ||
| 18:30 | CDE Racing Féminas | - | CP Cacereño | 4:5 pso | ||
| 20:00 | CF Unión Viera | - | Dux Logroño | 0:2 | ||
| 14/09/2022 | Elche CF | - | Santa Teresa CD | 3:0 dec. | ||
| 15:30 | Deportivo La Coruña | - | CD Parquesol | 5:0 | ||
| 16:30 | Friol | - | Pozoalbense | 6:0 | ||
| 17:00 | Fundación Tenerife | - | CD Castellón | 5:1 | ||
| 18:00 | Fundación Albacete | - | CE Seagull | 4:0 | ||
| 18:15 | CE Europa | - | Zaragoza CFF | 3:0 | ||
| 19:00 | CD Femarguín | - | CD Juan Grande | 0:1 | ||
| 19:30 | Málaga CF | - | Granada CF | 0:1 | ||
| 15/09/2022 | 19:00 | CF La Solana | - | Real Oviedo | 0:2 | |
| 27/09/2022 | 15:00 | Real Unión de Tenerife | - | Levante Las Planas | 0:4 | |
| 28/09/2022 | 18:00 | Bizkerre | - | Alhama CF | 0:5 (0:2) |
