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| 30/01/2022 | 13:30 | Stade Briochin | - | Stade Brestois 29 | 1:4 (1:1) | |
| 13:30 | AS Vitré | - | FC Nantes | 0:3 (0:2) | ||
| 13:30 | RC Argenteuil | - | SM Caen | 0:2 (0:0) | ||
| 13:30 | Havre AC | - | Paris Saint-Germain | 1:0 (1:0) | ||
| 13:30 | Angers SCO | - | US Avranches | 3:4 (1:1, 2:2) pso | ||
| 13:30 | Valenciennes FC | - | Stade Rennais | 4:5 (0:1, 1:1) pso | ||
| 13:30 | US Quevilly-Rouen | - | Amiens SC | 0:3 (0:1) | ||
| 13:30 | USM Saran | - | US Boulogne | 4:2 (0:0, 1:1) pso | ||
| 13:30 | Paris 13 Atletico | - | ASPTT Marseille | 3:1 (2:0) | ||
| 13:30 | OGC Nice | - | AC Ajaccio | 0:1 (0:0) | ||
| 13:30 | Olympique de Valence | - | ESTAC Troyes | 0:4 (0:4) | ||
| 13:30 | RC Strasbourg | - | Montpellier HSC | 5:4 (2:0, 3:3) pso | ||
| 13:30 | Canet Roussillon | - | AJ Auxerre | 5:4 (0:0, 1:1) pso | ||
| 13:30 | AS Monaco | - | Olympique Lyonnais | 2:4 (0:1, 1:1) pso | ||
| 13:30 | FC 93 Bobigny | - | ASPTT Dijon | 2:1 (2:0) | ||
| 14:30 | Lyon-La Duchère | - | Clermont Foot 63 | 4:2 (1:1, 1:1) pso |
